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Publications 2022


  1. Simon C, Zidi M. Regional variation in the mechanical properties of the skeletal muscle. J Mech Behav Biomed Mater. Doi: 10.1016/j.jmbbm.2022.105521
  2. Guihard M, Gracies JM, Baude M. Three-Dimensional Quantification of Facial Morphology and Movements Using a Wearable Helmet. Biomed Res Int. Doi:10.1155/2022/2774713.
  3. Pradines M, Ghédira M, Bignami B, Vielotte J, Bayle N, Marciniak C, Burke D, Hutin E, Gracies JM. Do Muscle Changes Contribute to the Neurological Disorder in Spastic Paresis? Doi:10.3389/fneur.2022.817229.
  4. Jamin P, Duret C, Hutin E, Bayle N, Koeppel T, Gracies JM, Pila O. Using Robot-Based Variables during Upper Limb Robot-Assisted Training in Subacute Stroke Patients to Quantify Treatment Dose. Sensors (Basel). Doi:10.3390/s22082989.
  5. Boulay C, Sangeux M, Authier G, Jacquemier M, Merlo A, Chabrol B, Jouve JL, Gracies JM, Pesenti S. Reduced plantar-flexors extensibility but improved selective motor control associated with age in young children with unilateral cerebral palsy and equinovalgus gait. J Electromyogr Kinesiol. 2022 Aug;65:102665. Doi:10.1016/j.jelekin.2022.102665.
  6. Ghédira M, Pradines M, Mardale V, Gracies JM, Bayle N, Hutin E. Quantified clinical measures linked to ambulation speed in hemiparesis. Top Stroke Rehabil. Doi:10.1080/10749357.2021.1943799.

Publications 2021


  1. Farid L, Jacobs D, Do Santos J, Simon O, Gracies JM, Hutin E. FeetMe® Monitor-connected insoles are a valid and reliable alternative for the evaluation of gait speed after stroke. Top Stroke Rehabil. 2021 Mar;28(2):127-134. Doi: 10.1080/10749357.2020.1792717.
  2. Jacobs D, Farid L, Ferré S, Herraez K, Gracies JM, Hutin E. Evaluation of the Validity and Reliability of Connected Insoles to Measure Gait Parameters in Healthy Adults. Sensors (Basel). Doi: 10.3390/s21196543.
  3. Gracies JM, Francisco GE, Jech R, Khatkova S, Rios CD, Maisonobe P. Guided Self-rehabilitation Contracts Combined With Abobotulinum toxin A in Adults With Spastic Paresis. J Neurol Phys Ther. Doi: 10.1097/NPT.0000000000000359.
  4. Esquenazi A, Brashear A, Deltombe T, Rudzinska-Bar M, Krawczyk M, Skoromets A, O’Dell MW, Grandoulier AS, Vilain C, Picaut P, Gracies JM. The Effect of Repeated abobotulinumtoxinA (Dysport®) Injections on Walking Velocity in Persons with Spastic Hemiparesis Caused by Stroke or Traumatic Brain Injury. PM R. Doi: 10.1002/pmrj.12459.
  5. Ghédira M, Albertsen IM, Mardale V, Loche CM, Vinti M, Gracies JM, Bayle N, Hutin E. Agonist and antagonist activation at the ankle monitored along the swing phase in hemiparetic gait. Doi: 10.1016/j.clinbiomech.2021.105459.

Publications 2020


  1. Bellicha A, Coupaye M, Hocquaux L, Speter F, Oppert JM, Poitou C. Increasing physical activity in adult women with Prader-Willi syndrome: a transferability stud. J Appl Res Intellect Disabli. Doi: 10.1111/jar.12669
  2. Bellicha A,Giroux C, Ciangura C, Menoux D, Thoumie P, Oppert JM, Portero P. Vertical jump on a force plate for assessing muscle strength and power in women with severe obesity: reliability, validity and relations with body composition. J Strength Cond Res. Doi: 10.1519/JSC.0000000000003432.
  3. Gracies JM, Jech R, Valkovic P, Marque P, Vecchio M, Denes Z, Vilain C, Delafont B, Picaut P. When can maximal efficacy occur with repeat botulinum toxin injection in upper limb spastic paresis? Brain Commun. Doi: 10.1093/braincomms/fcaa201.

Publications 2019


  1. Jalal N, Zidi M. Influence of experimental conditions on visco-hyperelastic properties of skeletal muscle tissue using Box-Behnken design. Journal of Biomechanics, Volume 85, p. 204-209. Doi: 10.1016/j.jbiomech.2019.01.020.1. 
  2. Gracies JM, Pradines M, Ghédira M, Loche CM, Mardale V, Hennegrave C, Gault-Colas C, Audureau E, Hutin E, Baude M, Bayle N; Neurorestore Study Group. Guided Self-rehabilitation Contract vs conventional therapy in chronic stroke-induced hemiparesis: NEURORESTORE, a multicenter randomized controlled trial. BMC Neurol., vol 19(1): 39. Doi: 10.1186/s12883-019-1257-y.
  3. Marais L, Pernot M, Khettab H, Tanter M, Messas E, Zidi M, Laurent S, Boutouyrie P. Arterial Stiffness Assessment by Shear Wave Elastography and Ultrafast Pulse Wave Imaging: Comparison with Reference Techniques in Normotensives and Hypertensives. Ultrasound in Medicine and Biology, vol 45(3), p. 758-772. Doi: 10.1016/j.ultrasmedbio.2018.10.032.
  4. Pradines M, Ghedira M, Portero R, Masson I, Marciniak C, Hicklin D, Hutin E, Portero P, Gracies JM, Bayle N. Ultrasound Structural Changes in Triceps Surae After a 1-Year Daily Self-stretch Program: A Prospective Randomized Controlled Trial in Chronic Hemiparesis. Neurorehabil Neural Repair, vol 33(4): 245-259. Doi: 10.1177/1545968319829455.
  5. Jalal N, Gracies JM, Zidi M. Mechanical and microstructural changes of skeletal muscle following immobilization and/or stroke. Biomech Model Mechanobiol. Doi: 10.1007/s10237-019-01196-4.
  6. McAllister PJ, Khatkova SE, Faux SG, Picaut P, Raymond R, Gracies JM. Effects on walking of simultaneous upper/lower limb abobotulinumtoxina injections in patients with stroke or brain injury with spastic hemiparesis. J Rehabil Med. Doi: 10.2340/16501977-2604.
  7. McAllister PJ, Khatkova SE, Faux SG, Picaut P, Raymond R, Gracies JM. Effects on walking of simultaneous upper/lower limb abobotulinumtoxina injections in patients with stroke or brain injury with spastic hemiparesis. J Rehabil Med. Doi: 10.2340/16501977-2604.
  8. Bellicha A, Ciangura C, Roda C, Torcivia A, Portero P, Oppert JM. Changes in Cardiorespiratory Fitness After Gasttric Bypass: Relations with Accelerometry-Assessed Physical Activity. Obes Surg., vol 29(9):2936-2941.
  9. Taoum A, Sadqi R, Zidi M, D’Anglemont de Tassigny A, Ngote N, Megdiche K. On the Use of Anatomage Table as Diagnostic Tool. International Journal of Biology and Biomedical Engineering.

Publications 2018


  1. Birnbaum S, Hogrel JY, Porcher R, Portero P, Clair B, Eymard B, Demeret S, Bassez G, Gargiulo M, Louët E, Berrih-Aknin S, Jobic A, Aegerter P, Thoumie P, Sharshar T, MGEX Study Group. The benefits and tolerance of exercise in myasthenia gravis (MGEX): study protocol for a randomised controlled trial. Trials. Doi: 10.1186/s13063-017-2433-2.
  2. Jalal N., Zidi M. Effect of cryopreservation at -80°C on visco-hyperelastic properties of skeletal muscle tissue. Journal of the Mechanical Behavior of Biomedical Materials.
  3. Lorentzen J, Pradines M, Gracies JM, Bo Nielsen J. On Denny-Brown’s ‘spastic dystonia’ – What is it and what causes it? Clinical Neurophysiology. DOI:10.1016/j.clinph.2017.10.023
  4. Mardale V, Hutin E, Guihard M, Gault-Colas C, Bayle N, Gracies JM. Approche neurorééducative des tremblements. Evaluation clinique, traitements (2e partie). Kinésithér Scient.
  5. O’Dell MW, Brashear A, Jech R, Lejeune T, Marque P, Bensmail D, Ayyoub Z, Simpson DM, Volteau M, Vilain C, Picaut P, Gracies JM. Dose-Dependent Effects of AbobotulinumtoxinA (Dysport) on Spasticity and Active Movements in Adults With Upper Limb Spasticity: Secondary Analysis of a Phase 3 Study. PM&R. Doi: 10.1016/j.pmrj.2017.06.008
  6. Giroux C., Roduit B., Rodriguez-Faces J., Duchateau J., Maffiuletti N.A., Place N. Short vs. long pulses for testing knee extensor neuromuscular properties: does it matter? Eur J Appl Physiol. Doi: 10.1007/s00421-017-3778-7
  7. Gracies JM, O’Dell M, Vecchio M, Hedera P, Kocer S, Rudzinska-Bar M, Rubin B, Timerbaeva SL, Lusakowska A, Boyer FC, Grandoulier AS, Vilain C, Picaut P. AbobotulinumtoxinA Adult Upper Limb Spasticity. International Study Group: Effects of repeated abobotulinumtoxinA injections in upper limb spasticity. Muscle Nerve. Doi: org/10.1002/mus.25721
  8. Vinti M, Gracies JM, Gazzoni M, Vieira T. Localised sampling of myoelectric activity may provide biased estimates of cocontraction for gastrocnemius though not for soleus and tibialis anterior muscles. J Electromyogr Kinesiol. Doi: 10.1016/j.jelekin.2017.11.003
  9. Hutin E, Ghédira M, Loche CM, Mardale V, Hennegrave C, Gracies JM, Bayle N. Intra- and inter-rater reliability of the 10-meter ambulation test in hemiparesis is better barefoot at maximal speed. Topics in Stroke Rehabilitation. Doi: 10.1080/10749357.2018.1460932
  10. Pila O, Duret C, Gracies JM, Francisco GE, Bayle N, Hutin E. Evolution of upper limb kinematics four years after subacute robot-assisted rehabilitation in stroke patients. Int J of Neurosci. Doi: 10.1080/00207454.2018.1461626.
  11. Safi K, Mohammed S, Attal F, Amirat Y, Oukhellou L, Khalil M, Gracies JM, Hutin E. Automatic Segmentation of Stabilometric Signals using Hidden Markov Model Regression. IEEE Transactions on Automation Science and Engineering. Doi: 10.1109/TASE.2016.2637165
  12. Vinti M, Bayle N, Merlo A, Authier G, Pesenti S, Jouve JL, Chabrol B, Gracies JM, Boulay C. Muscle Shortening and Spastic Cocontraction in Gastrocnemius Medialis and Peroneus Longus in Very Young Hemiparetic Children. BioMed Research International. Doi: org/10.1155/2018/2328601
  13. Zidi M., Allaire E. Mechanical properties change in the rat xenograft model treated by mesenchymal cells cultured in an hyaluronic acid-based hydrogel. Journal of Mechanics in Medicine and Biology. Doi: org/10.1142/S0219519418500471
  14. Pradines M, Baude M, Marciniak C, Francisco G, Gracies JM, Hutin E, Bayle N. Effect on passive range of motion and functional correlates following a long-term lower limb self-stretch program in patients with chronic spastic paresis. Physical Medicine and Rehabilitation (PM&R). Doi: org/10.1016/j.pmrj.2018.02.013

Myopathie Spastique

Dans la parésie spastique résultante d’un AVC, deux affections coexistent et s’entretiennent mutuellement :

  • La première est neurologique et est caractérisée par une parésie apparaissant dès les premières heures après la lésion, puis une hyperactivité musculaire se développant au stade subaigu, au sein de laquelle nous pouvons distinguer trois formes sensibles à l’étirement : la dystonie spastique (activité musculaire tonique présente au repos), la spasticité (augmentation des réflexes à l’étirement phasique dépendant de la vitesse), et la cocontraction spastique (activité musculaire de l’antagoniste lors de la commande volontaire de l’agoniste).
  • La deuxième affection est d’ordre musculaire. La perte de tension longitudinale liée à l’immobilisation en position courte de certains muscles (dont les muscles opposés sont les plus parétiques), induit une véritable maladie du muscle au sein des membres parétiques, la myopathie spastique, dont la chronologie des multiples transformations est bien plus précoce qu’initialement envisagée.

A la phase subaigüe, ces deux affections neurologique et musculaire interagissent, conduisant à l’apparition d’un cercle vicieux rétraction-hyperactivité-rétraction, au sein duquel la raideur musculaire renforce la réponse sensorielle des fuseaux neuro-musculaires primaires et secondaires, et par conséquent majore le temps quotidien d’activation musculaire, autrement dit, la présence de dystonie spastique ou de cocontraction spastique. Les mécanismes neurophysiologiques responsables de la dystonie spastique et de la co-contraction spastique restent encore à élucider.